Product Description of 4-(2-Tetrahydropyranyloxy)phenylboronic Acid CAS#182281-01-2
4-(2-Tetrahydropyranyloxy)phenylboronic acid is a functional organoboron intermediate, which is the tetrahydropyranyl-protected form of 4-hydroxyphenylboronic acid. At room temperature, it generally appears as a white to pale-yellow solid. The tetrahydropyranyl group effectively shields the phenolic hydroxyl group, preventing side-reactions during synthetic operations.
This boronic acid monomer exhibits good reactivity in common palladium-catalyzed cross-coupling transformations. It has limited solubility in water and dissolves readily in many anhydrous organic solvents.
4-(2-Tetrahydropyranyloxy)phenylboronic acid Chemical Properties
| Melting point | 117-124 °C |
| Boiling point | 411.3±55.0 °C(Predicted) |
| density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 8.63±0.16(Predicted) |
| color | White to Light yellow |
| CAS DataBase Reference | 182281-01-2(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi |
| Risk Statements | 36/37/38-20/21/22-36/38 |
| Safety Statements | 36/37/39-26-37/39-36 |
| HazardClass | IRRITANT |
| HS Code | 29329990 |
Product Application of 4-(2-Tetrahydropyranyloxy)phenylboronic Acid CAS#182281-01-2
This boronic-acid reagent is mainly applied for Suzuki-Miyaura cross-coupling reactions and acts as a vital synthetic intermediate in drug-development workflows.
It can be adopted to construct anti-cancer dichloroacetamide analogues and other bio-active molecular frameworks. The removable tetrahydropyranyl protecting group masks the hydroxyl site throughout multi-step synthetic routes, suppressing unwanted side reactions and improving overall reaction selectivity and product yield. Thanks to this protective-group structure, the compound is suitable for complex organic synthesis, especially for the manufacture of fine-chemical and pharmaceutical candidates.
